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郭乔月，青年PI、博士生导师。主要从事中枢神经-骨代谢调控机制，骨关节炎发病病理机制及骨对能量代谢调控机制等方面研究。于Advanced Science,Bone Research,Nature Communications,Cell Metabolism等期刊发表共发表SCI论文12篇，其中第一（含通讯）作者4篇。论文引用500余次，单篇最高引用100余次。获国家资助博士后研究人员计划（B档）。
v 个人经历
2024.08-至今 海南医科大学（海南省医学科学院）青年PI、博士生导师
2019.02-2023.09 Johns Hopkins University 联合培养博士、博士后
2016.09-2024.06 中南大学湘雅医院 内科学 博士
2010.09-2015.07 天津医科大学 临床医学 学士
v 研究方向
郭乔月团队致力于代谢性骨病发病机制与中枢神经-骨代谢调节机制研究。
v 代表性研究成果及转化
[1] Guo, Q., Chen, N., Qian, C., Qi, C., Noller, K., Wan, M., Liu, X., Zhang, W., Cahan, P., & Cao, X. (2023). Sympathetic Innervation Regulates Osteocyte-Mediated Cortical Bone Resorption during Lactation. Advanced Science, 10(18), 2207602.
[2] Guo, Q., Chen, N., Patel, K., Wan, M., Zheng, J., & Cao, X. (2023). Unloading‐Induced Skeletal Interoception Alters Hypothalamic Signaling to Promote Bone Loss and Fat Metabolism. Advanced Science, 2305042.
[3] Q. Guo, Q. Guo, Y. Xiao, C. Li, Y. Huang, X. Luo, Regulation of bone marrow mesenchymal stem cell fate by long non-coding RNA, Bone 141 (2020) 115617.
[4] G. Zhen, Q. Guo, Y. Li, C. Wu, S. Zhu, R. Wang, X.E. Guo, B.C. Kim, J. Huang, Y. Hu, Y. Dan, M. Wan, T. Ha, S. An, X. Cao, Mechanical stress determines the configuration of TGFβ activation in articular cartilage, Nat Commun 12(1) (2021) 1706.
[5] Zhou R, Guo Q, Xiao Y, Guo Q, Huang Y, Li C, Luo X, Endocrine role of bone in the regulation of energy metabolism, Bone Research 9(1) (2021) 25.
[6] X. Liu, Y. Chai, G. Liu, W. Su, Q. Guo, X. Lv, P. Gao, B. Yu, G. Ferbeyre, X. Cao, M. Wan, Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis, Nat Commun 12(1) (2021) 1832.
[7] Q. Sun, G. Zhen, T.P. Li, Q. Guo, Y. Li, W. Su, P. Xue, X. Wang, M. Wan, Y. Guan, X. Dong, S. Li, M. Cai, X. Cao, Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice, Elife 10 (2021) e66532.
[8] Zhen, G., Dan, Y., Wang, R., Dou, C., Guo, Q., Zarr, M., Liu, L. N., Chen, L., Deng, R., & Li, Y. (2021).
An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+ mononuclear cells and PDGF-BB secretion. Bone Research, 9(1), 47.
[9] M. Tu, M. Yang, N. Yu, G. Zhen, M. Wan, W. Liu, B. Ji, H. Ma, Q. Guo, P. Tong, L. Cao, X. Luo, X. Cao, Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis, Bone Research 7(1) (2019) 29.
[10] Liu, X., Gu, Y., Kumar, S., Amin, S., Guo, Q., Wang, J., Fang, C.-L., Cao, X., & Wan, M. (2023). Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow. Cell Metabolism, 35(4), 667-684. e666.
[11] Liu, X., Guo, Q., Wang, L., Gu, Y., Meng, S., Gu, Y., & Yu, B. (2023). Metformin attenuates high-fat diet induced metabolic syndrome related osteoarthritis through inhibition of prostaglandins. Frontiers in Cell and Developmental Biology 11, 1184524 (2023).
[12] Leser, J. M., Torre, O. M., Gould, N. R., Guo, Q., Buck, H. V., Kodama, J., ... & Stains, J. P. (2023). Osteoblast-lineage calcium/calmodulin-dependent kinase 2 delta and gamma regulates bone mass and quality. Proceedings of the National Academy of Sciences, 120(47), e2304492120.
